This is largely due to its role in relaxing soft muscle tissue, specifically the anal sphincter, and its ability to enhance pleasure and reduce pain for anyone engaging in anal sex. But by the 1970s, poppers had become a popular club drug, most notably in relation to gay nightlife and the LGBTQ community. Vasodilators were first used in 1867 by Thomas Lauder Brunton as a medical treatment for angina pectoris (chest pain). The widening of your blood vessels also causes smooth muscle tissue throughout your body to relax. As your heart doesn’t have to work as hard, the increase in blood flow causes your blood pressure to drop. Alkyl nitrites are vasodilators that cause your blood vessels to widen and your blood flow to increase. Poppers belong to a class of drugs called alkyl nitrites. LGBTQ+ health specialist Henry Ng, MD, shares why poppers have become increasingly popular and controversial over the last decade, along with some of the dangers and risks. ![]() We do not endorse non-Cleveland Clinic products or services. ![]() Advertising on our site helps support our mission. Cleveland Clinic is a non-profit academic medical center.
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